All systems will fail eventually. A fail-safe design will minimize the damage to people and equipment. Consider the selection electrical connections. If wires are cut or connections fail, the equipment should still be safe. For example, if a normally closed stop button is used, and the connector is broken, it will cause the machine to stop as if the stop button has been pressed.
NC (Normally Closed) - When wiring switches that stop processes use normally closed so that if they fail the process will stop. E-Stops must always be NC, and they must cut off the master power, not just be another input to the PLC.